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The 18 Best Peptide Serums and Creams of 2023 for Anti-Aging

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Since peptides also bind and lock in moisture, they also make for a good ingredient in a moisturizer. Rodney says they provide a collagen boost, and since they’re humectants, they work well for dry, oily, and combination skin types.

“A peptide cream … infuses high concentrations of peptides into your skin over a period of time,” Libby explains. “I would recommend a cream-based formula for those looking for more hydration and moisturization for their skin, as well as those looking to improve visible signs of aging like fine lines and wrinkles, discolorations, and loss of elasticity and firmness.”

When shopping for a peptide cream, look closely at the ingredient list and do your research on brands and specific products. “Although peptides help with anti-aging, I want my cream to not stray from its primary function, which is to keep my skin moisturized and lock in moisture. (Peptides do help in this area too.) You can look for peptides or polypeptides on the ingredient list, along with glycerin, hyaluronic acid, and other humectants,” Rodney says.

Here are some peptide cream options below.


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