But standing in their way is a tricky looking tie against Fulham, who have impressed in their first season back in the Premier League under the guidance of Marco Silva.
The Cottagers have not reached the semi-finals of the famous old competition for 21 years, and to do so they must end a run of 15 games without a win against United in all competitions.
Here is what time Manchester United vs Fulham kicks-off this weekend and how you can watch it on TV and live stream.
What time does Manchester United vs Fulham kick-off?
The game will kick-off on Sunday, March 19 at 4:30pm.
How to watch on TV and live stream
Manchester United vs Fulham will be shown on ITV 1, with coverage getting underway from 3.45pm.
A live stream will also be available to watch on ITV X.
How to listen on radio
Live radio commentary will take place on talkSPORT from 4pm.
What happens if the game finishes level?
If the match finishes all square after 90 minutes, then the cup tie will head straight to extra-time and if required, penalties.
Replays were in use in this season’s competition up until the fifth round.
Replays were first scrapped at the quarter-final stage in 2015 in an attempt to reduce fixture congestion in the football calendar.
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